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doi: 10.1007/s00125-002-1028-x 19 SchirraJNicolausMWoerleHJStruckmeierCKatschinskiMGkeBet al

Clinical trials demonstrate that patients receiving liraglutide showed 18% slower cognitive decline over one year compared to placebo 30

Balanced Perspective: Conditional Game Changer The evidence suggests that GLP-1 agonists represent a conditional game changertransformative for appropriate patients with adequate access and support, but with significant limitations that prevent universal application

Importantly, efpeglenatides immunogenicity remained relatively low, with few patients developing clinically significant anti-drug antibodies, allowing its safety profile to be viewed as manageable within class expectations

Similarly, expression of cell signature genes, transthyretin ( TTR ), vitamin Dbinding protein ( GC ), crystallin A2 ( CRYBA2 ), aldehyde dehydrogenase 1 family member A1 ( ALDH1A1 ), and transmembrane 4 L 6 family member 4 ( TM4SF4 ), was highest in the -3 and 4 subclusters (Figure 3D)

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